PPAR-γ ligands (rosiglitazone and GW1929, but not PGJ2)were also recently reported to inhibit the expression of the gene encoding forthe α5 integrin subunit resulting in reduced expression of theintegrin α5β1, a fibronectin receptor that mediates fibronectin’s mitogeniceffects in NSCLC cells and nontumor lung cells [96]. The gene discussed is FN1; the disease is non-small cell lung carcinoma.