PPARG and neoplasm: Also, PPAR-γ ligands can inhibit the transdifferentiation of fibroblastsinto myofibroblasts, a phenotype similar to that of tumor-associated fibroblasts,in several fibrotic conditions [99–102].A recent study demonstrated that PPAR-γ ligands completely reverse the antitumor cytotoxicT-lymphocyte suppressive activity and the M2 phenotype of tumor-associatedmacrophages [103].