PPAR-γ ligands are also known to inhibit the expression of severalcytokines and chemokines produced by all of the major cell types present in thetumor microenvironment (60, 61, 97, 98].Together with data showing effects on fibronectin matrix expression andrecognition in NSCLC [95], the above observations suggest that PPAR-γ might be a novel candidate for targeting the tumormicroenvironment. Here, PPARG is linked to non-small cell lung carcinoma.