CASP1 and diabetes mellitus: Inhibition of caspase-1 using minocycline inhibited the diabetes-induced increase in IL-1β and decreased degeneration ofretinal capillaries in those animals [34].Likewise, inhibition of IL-1β signaling using IL-1β receptor knock-outmice protected the animals from diabetes-induced retinal pathology at 7 monthsduration of diabetes [34].