NFKB1 and diabetes mellitus: Binding of AGEs or other relatedmolecules to their extracellular receptors such as RAGE (receptor for advancedglycation endproducts) have a variety of intracellular effects, includingactivation of the proinflammatory NF-κB and stimulation of leukostasis[138–143].Pharmacological interventions interrupting RAGE-ligandinteraction inhibit diabetes-induced degeneration of retinal capillaries indiabetes [25], but whether or not this is mediated by inhibition of NF-κB has not been explored.