Evidence using retinal tissue from diabeticanimals or incubated in high glucose indicates that (a) PARP regulates activityof NF-κB as well as expression of ICAM-1 [72], (b) inhibition of NF-κB with sulfasalazine inhibits expression of iNOS, ICAM-1, VCAM, COX-2 [74, 148], (c)inhibition of iNOS inhibits the hyperglycemia-induced generation ofprostaglandin [33], whereas the opposite reaction (regulation of nitric oxideproduction by COX-2) was not detected, and (d) inhibition of COX inhibitsexpression of ICAM-1 and leukostasis [21]. Here, ICAM1 is linked to Hyperglycemia.