IL1B and diabetic retinopathy: The role of IL-1β in the pathogenesis of diabetic retinopathy recently has been moredirectly studied using diabetic mice in whomthe enzyme responsible for IL-1β production was inhibited or in whom the IL-1β receptor was deleted.IL-1β is the predominant product of caspase-1, and the biological activity of IL-1β is mediated by binding to the cell surface receptor, IL-1R1.