Blocking FasL in vivo hasbeen shown to prevent endothelial cell damage, vascular leakage, and plateletaccumulation in diabetes, suggesting that the Fas/FasL system might contributeto the diabetes-induced damage that contributes to the development of theretinopathy [128], but its role in the development of retinal histopathologyhas not been assessed. Here, FASLG is linked to diabetes mellitus.