CD86 and chronic myelogenous leukemia, BCR-ABL1 positive: Cellular spreading of murine macrophages in response to PMA requires intracellular Ca2+[28], treatment of malignant myeloid progenitor cells from patients with chronic myelogenous leukemia with a calcium ionophore leads to expression of CD86 and other surface markers including those for dendritic cell-activation and adhesion [57], and expression of CD86 in human monocyte-derived dendritic cells is also increased by elevated Ca2+ flux [58].