AKT1 and neoplasm: Univariate analysis (Cox model) identified tumor size (HR 2.42, C.I. 1.25–4.68, p = 0.009), grading (G3, HR 4.78, C.I. 1.05–21.69, p = 0.04), nodal status (HR 2.25, C.I. 1.15–4.39, p = 0.018), ErbB-3 (HR 3.01, C.I. 1.56–5.82, p = 0.001), P-Akt overexpression (HR 5.03, C.I. 1.90–13.32, p = 0.001) and lack of ER β1 (HR 3.88, C.I. 1.98–7.59, p<0.0001) as significant predictors of DFS.