S100A7 and breast cancer: Psoriasin/S100A7 is known to correlate with indicators of poor prognosis, specifically in ERα− breast cancers, and may represent an independent prognostic factor for clinical outcome.30,35,36 To investigate SBEM protein expression further in separate subgroups, we divided the patient cohort according to ER status (as determined by both the ligand binding assay and IHC).