Other SOX factors, such as SOX4 and SOX9, have been reported as tumour-suppressive proteins in bladder (Aaboe et al, 2006), breast (Afonja et al, 2002), prostate (Drivdahl et al, 2004) and colon carcinomas (Jay et al, 2005). The gene discussed is SOX4; the disease is colon carcinoma.