A multivariate Cox regression model including cortactin, cyclin D1, FADD, treatment and lymph node metastasis showed that cortactin expression (HR=8.46; 95% CI, 1.63–43.88; P=0.011) and lymph node metastasis (HR=3.96; 95% CI, 1.30–12.06; P=0.015) were predictors for increased DSM, whereas FADD and cyclin D1 were not (Table 4A). Here, FADD is linked to metastatic malignant neoplasm in the lymph nodes.