ERCC2 and colorectal carcinoma: In Caucasian patients with advanced CRC who are treated with oxaliplatin, 5 FU and leucovorin (LV), ERCC1 118 T/T, XRCC1 (Arg – >Gln substitution in exon 10), ERCC2 751AC, and ERCC2 751CC genotypes are independently associated with poor progression-free survival and short-term survival [13,14].