This study suggests that CRC patients who have the ERCC2 2251AC (751Lys/Gln) or 2251CC (751Glu/Gln) genotypes have a significantly increased early relapse risk (OR = 3.294; 95% CI, 1.272–8.532), and no statistically significant correlation exists between genotype distributions and clinicopathological features (all P > 0.05). The gene discussed is ERCC2; the disease is colorectal carcinoma.