INS and metabolic syndrome: Collectively, these studies have found that ADT leads to an increase in fat mass, an increase in plasma insulin, decreased insulin sensitivity (48), increased levels of glycosylated haemoglobin, an increase in plasma cholesterol, LDL-cholesterol and triglycerides but also an increase in plasma HDL-cholesterol, which contrasts with the low HDL-cholesterol levels found in the metabolic syndrome.