We also showed that MyD88-mediated signaling was involved in the innate immune response stimulated by the flmK mutant, as the augmented cytokine response of BMMø to this mutant required MyD88, and infection with the flmK mutant was lethal in mice lacking MyD88 (albeit with delayed kinetics in comparison to the lethality of WT Fn infection in C57BL/6 mice). This evidence concerns the gene MYD88 and infection.