The Th2 cytokine milieu induced by helminth infection is thought to drive the antibody response of malaria co-infected individuals towards the production of non-cytophilic subclasses (IgG2, IgG4, and IgM), whereas protection against malaria is associated with the presence of the IgG1 and IgG3 cytophilic subclasses [11]. The gene discussed is CD40LG; the disease is malaria.