IGF1 and renal fibrosis: In those reports two different peptides (one peptide was a partial analogue of IGF-I C terminal, while another has reversed sequences compared to the first one, but both peptides were named as JB3) were found to inhibit early renal tissue growth in diabetic and uninephrectomized rats but did not inhibit renal fibrosis, in which IGF-I is also involved [32,33].