LOXL1 and open-angle glaucoma: To determine if the results from the Nordic study are generalizable to a heterogeneous population from the North eastern United States, we used an existing sample (206 PXF, 331 POAG, and 88 controls) from the Glaucoma Consultation Service at the Massachusetts Eye and Ear Infirmary to provide independent estimates of the association of LOXL1 SNPs with the pseudoexfoliation syndrome and pseudoexfoliation glaucoma.