EGFR and non-small cell lung carcinoma: Among EGFR-TKIs, gefitinib and erlotinib have been extensively evaluated in non-small cell lung cancer (NSCLC), and sensitivity to these drugs has been associated with the presence of somatic mutations in the EGFR kinase domain or with EGFR amplification (Lynch et al, 2004; Paez et al, 2004; Pao et al, 2004; Cappuzzo et al, 2005; Mitsudomi et al, 2005; Takano et al, 2005).