The oral TRPV1 antagonist JNJ 10185734 has been reported to attenuate dextran sulfate sodium (DSS)-induced colitis in mice, suggesting a possible role for TRPV1 in initiation or maintenance of inflammation in the gut.42 Other previous animal studies strengthen the view that TRPV1 is involved in inflammation and hyperalgesia. The gene discussed is TRPV1; the disease is colitis.