TRPV1 is expressed throughout the gastrointestinal (GI) tract in myenteric ganglia, muscular layers and mucosa.10 Our previous studies have shown changes of TRPV1 in upper and lower GI disorders: in inflammatory bowel disease, we reported greatly increased TRPV1 immunoreactivity in biopsies taken from patients with active painful Crohn’s disease compared with controls (Yiangou et al10). Here, TRPV1 is linked to Crohn disease.