Earlier, Hosaka et al. [20] had used a similar combination of immunohistochemical (with anti-chromogranin A) and histochemical (PAS/alcian blue) method for a simultaneous detection of endocrine cells and mucin-secreting cells, to present a case with an early-stage colon adenocarcinoma with neuroendocrine differentiation. Here, CHGA is linked to colon adenocarcinoma.