CYP3A5 and hypertensive disorder: Furthermore, considering the hypertension-associated SNPs, whilst the Kashmiri group had a significantly lower MAF for the CYP3A5 g.6980G>A SNP compared to the other groups, this language group also had the highest MAF for the AGT g.802C>T SNP and the second highest MAF for the GNB3g.4423C>T SNP (Table 2).