We observed a progressive reduction in RBL2/p130 transcripts from NC to mild/moderate dysplasia and severe dysplasia suggesting that a reduction in RBL2/p130 may also be regulated at the transcriptional level in cervical preneoplasia and may be the first Rb family gene event in the development of cervical intraepithelial neoplasia. The gene discussed is RBL2; the disease is cervical intraepithelial neoplasia.