VCAN and leiomyoma: Versican (3·05 ± 0·79-fold, P < 0·05), CYP26A1 (19·16 ± 3·98-fold, P < 0·05) and TGF-β3 (2·6 ± 1·02-fold, P < 0·05) demonstrated increased gene expression in leiomyoma cells, similar to the primary cultures and progenitor tissue.8 Changes in expression of these genes were maintained throughout multiple cell passages for both leiomyoma and myometrial cell cultures (data not shown).