We have previously shown that cellular retinol binding protein (CRBP-1) was down-regulated in leiomyoma tissue as compared to myometrium.6 In this study, we have demonstrated that our immortalized cell lines also show a similar threefold down-regulation of CRBP-1 mRNA expression (0·38 ± 0·14; P < 0·05) in untreated leiomyoma cells compared to myometrial cells (Table 1). Here, RBP1 is linked to leiomyoma.