Using the Eker rat leiomyoma model, a genetic model generated by the disruption tuberous sclerosis 2 gene expression, Gamage and coworkers34 demonstrated that use of retinoid X receptor-selective agonist, LGD 1069, reduced the number of grossly observable tumours due to increased apoptosis, but not the total incidence, suggesting that RA agonists can inhibit leiomyoma growth. The gene discussed is TSC2; the disease is leiomyoma.