With only HNSCC patients included, IL-6 secretion at SFM predicted survival as follows: Cox regression survival analyses, showed that LPS-stimulated monocyte IL-6 secretion, adjusted for gender and age of patients, predicted both total as well as disease-specific survival (p < 0.05) when analysed with original results (Table 2, upper panel) and when analysed dichotomised (Hazard ratio (HR) = 2.27; Confidence interval (CI) = 1.05–4.88; p < 0.05 and HR = 2.68; CI = 1.11–6.45;p < 0.05, respectively) (Table 3, upper panel). This evidence concerns the gene IL6 and head and neck squamous cell carcinoma.