Similarly, in K14-HPV16 female transgenic mice whose estrogen levels are maintained by time-release implants (HPV/E2 mice), incipient neoplasias first appear in the transformation zone, arising out of the HPV-16 oncogene-expressing squamous epithelium; the progressive neoplastic lesions are associated with an aberrant (“reactive”) stroma [28]. Here, KRT14 is linked to neoplasm.