Directed expression of the oncogenes contained in the early region of HPV16 to their apparent target cell type in humans, the basal squamous epithelial cell, by way of expression under control of the keratin 14 (K14) promoter in transgenic mice, leads to the formation of squamous cell carcinomas (SCC) of the skin; the skin tumors arise with 50% penetrance between 6–12 mo of age in the FVB/n mouse strain [22]. Here, KRT14 is linked to squamous cell carcinoma.