TF and acute respiratory distress syndrome: The hTF-KI animals and the specific antibody may offer us a useful model system to better characterize and understand the effects of anti-TF therapy in ALI models induced by other insults, such as sepsis, ventilator-induced lung injury, bacterial infection, etc. Results from these studies may provide additional information about the role of TF, as well as the potential therapeutic efficacy of CNTO859.