The hTF-KI animals and the specific antibody may offer us a useful model system to better characterize and understand the effects of anti-TF therapy in ALI models induced by other insults, such as sepsis, ventilator-induced lung injury, bacterial infection, etc. Results from these studies may provide additional information about the role of TF, as well as the potential therapeutic efficacy of CNTO859. The gene discussed is TF; the disease is bacterial infectious disease.