TF and hepatocellular carcinoma: Based on univariate analysis, the following numerous variables were picked up for potential factors for HCC development: (1) gender and duration of infection, (2) hepatic inflammation (serum ALT and AST levels and histological grade), (3) hepatic fibrosis (hyaluronic acid, platelet count, and histological stage), (4) iron-related markers (haemoglobin, serum iron, transferrin saturation, ferritin, and TIS), (5) serum HCV-RNA titres, and (6) hepatocytic 8-OHdG counts.