The frequency of hTR expression in cancers that result in advanced intra-abdominal disease and ascites, the accessibility of these tumours both for intra-peritoneal administration of Ad-hTR-NTR and for repeat analysis of ascitic fluid for pharmacodynamic endpoints, means that these tumours are a good test model for this ‘proof-of-principle’ clinical trial of telomerase-specific suicide gene therapy. Here, NTSR1 is linked to neoplasm.