VEGFA and neoplasm: The epidermal growth factor receptor (EGFR) tyrosine kinase family and the vascular endothelial growth factor (VEGF) superfamily are also well-known mediators of tumour cell proliferation and tumour-related angiogenesis, which can influence tumour biology and survival (Carmeliet and Jain, 2000; Gamboa-Dominguez et al, 2004; Juttner et al, 2006).