EGFR and colorectal cancer: Vallbohmer et al (2006) reported that high mRNA expression of EGFR was associated with a better response as well as longer progression-free and overall survival in patients with colorectal cancer who received irinotecan therapy, which is partially in accord with our findings. In contrast, Gamboa-Dominguez et al (2004) found that strong membranous staining of EGFR on immunohistochemical analysis correlated with poor survival.