EPHB4 and neoplasm: Among them, EphB4 and ephrinB2 arbitrate the enhanced proliferation, migration and metastatic potential of tumour cells (Vogt et al, 1998; Easty et al, 1999; Brantley et al, 2002; Cheng et al, 2002; Lawrenson et al, 2002; Pawson, 2002).