High levels of Eph expression have been reported in various cancer cell lines and cancer specimens, including cancer of the breast (Zantek et al, 1999; Zelinski et al, 2001), prostate (Walker-Daniels et al, 1999), colon (Rosenberg et al, 1997), oesophagus (Miyazaki et al, 2003), lung (Kinch et al, 2003), uterine endometrium (Alam et al, 2007) and in metastatic melanoma (Easty and Benett, 2000). Here, EPHA1 is linked to metastatic melanoma.