SPP1 and myocardial infarction: Clinical and epidemiological studies have implicated vascular calcification in myocardial infarction [1], instability and rigidity of the arterial wall [2], bioprosthetic valve failures [3], etc. In spite of the evidence that both physiological and pathological calcification is regulated through gene expressions of osteopontin (OPN) [4], matrix γ-carboxyglutamate protein (MGP) [5], and osteoprotegerin (OPG) [6], the mechanisms whereby calcium phosphate minerals are initially deposited in the arterial wall remain uncertain [7-9].