CCN2 and central nervous system cancer: siRNAs against CTGF lead to significant reduction of in vitro glioma migration (inhibition of up to 41% in T98G, p < 0.001, up to 30% in SNB19, p < 0.01 and up to 58% in U251, p < 0.001) as compared to luciferase control (Figure 5B).