Besides the observation that DCX is a marker for the minimal residual disease in human neuroblastoma [6], our results provides the new evidence that this protein is not present in all cell subtypes composing SK-N-SH cell line but it is express only in the more aggressive neuroblastoma cell subpopulation and in the retinoic acid-resistant cells that possess high motility and invasiveness. Here, DCX is linked to neuroblastoma.