We next examined the effects of curcumin and/or TRAIL on the expression of Bcl-2 family members (Bax, Bak, Bcl-2, and Bcl-XL) and death receptors (TRAIL-R1/DR4 and TRAIL-R2/DR5) by immunohistochemistry in tumor tissues derived from in vivo experiment (Fig. 2). The gene discussed is BAK1; the disease is neoplasm.