In summary, our systematic analysis of differential gene expression in the family of inter-alpha-trypsin inhibitors leads to the following conclusions: ITIH2, ITIH3, ITIH4, and ITIH5 are strongly downregulated in a variety of human solid tumors (see Fig. 2, Table 4); therefore, the ITIH genes are potential candidates as tumor suppressor or metastasis repressor genes. Here, ITIH4 is linked to neoplasm.