In particular, tumor suppressive effects have been attributed to the ITIH genes before: The short arm of chromosome 3 (3p), which ITIH1, ITIH3, and ITIH4 map to (see Table 1), is known to be a site of frequent genetic alterations in the evolvement of various human cancers (e.g. renal cell carcinoma[60], lung carcinoma[61], and others). This evidence concerns the gene ITIH3 and renal cell carcinoma.