RAB5A and infection: We found that early in infection, 65–70% of the CCVs co-localized with the early endosomal markers Rab4, Rab5, and with a probe for phosphoinisitide 3 phosphate (green fluorescent protein fused to the PX domain of the 40 kD subunit of the nicotinamide adenine nucleotide phosphate oxidase) (Figure 5B-5D, Figure S3 and Video S1).