Gene expression data from the microarray analysis of 92 primary breast tumors (from the UNC Microarray Database) were analyzed for expression of the six genes (CEACAM6, CDH1, CST6, ESR1, LCN2, and SCNN1A) whose loss characterizes the hypermethylator phenotype among breast cancer cell lines. The gene discussed is LCN2; the disease is breast carcinoma.