Since then, low expression or mutation of NM23-H1 has been implicated in cancer prognosis or metastasis in a variety of tumours and malignant transformation (Leone et al, 1991; Yih et al, 2002; Fan et al, 2003; Zhao and Li, 2004; Ma et al, 2005). The gene discussed is NME1; the disease is neoplasm.