In addition, a putative functional SNP, +331C/T (sometimes denoted as +331G/A), in the promoter region of the PGR that may affect the relative transcription of the PR-A and PR-B isoforms has been found to be associated with a reduced risk of ovarian cancer in studies from North Carolina and Australia (Berchuck et al, 2004). This evidence concerns the gene S100A6 and ovarian carcinoma.