IGFBP1 and pancreatic neoplasm: Other highly upregulated genes were related to protease inhibition such as Serpina1a, Serpina1c, Ambp [25-27]and insulin growth factor binding proteins such as Igfbp1 and Ifgbp2 [28-31], which have been shown to be upregulated in human pancreatic cancer as well as in the animal models of either pancreatic cancer or other types of cancer.