Other highly upregulated genes were related to protease inhibition such as Serpina1a, Serpina1c, Ambp [25-27]and insulin growth factor binding proteins such as Igfbp1 and Ifgbp2 [28-31], which have been shown to be upregulated in human pancreatic cancer as well as in the animal models of either pancreatic cancer or other types of cancer. Here, IGFBP1 is linked to cancer.