These results are not only consistent with the report by Verras et al. [42] that Wnt3A conditional medium promotes LNCaP cell growth both in ligand-dependent and independent manners, but they also agree with the observation that Wnt3a stimulated proliferation selectively in the AR positive prostate cancer cells, but not in AR negative cells [45]. This evidence concerns the gene WNT3A and Familial prostate cancer.