Up-regulation of the beta-catenin pathway has been suggested in chronic myeloid leukaemia (CML)-derived granulocyte-macrophage progenitor cells (GMPs) and multiple myeloma (MM) cells (Derksen et al, 2004; Jamieson et al, 2004). The gene discussed is CTNNB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.