Recently, a CD8 positive T cell epitope of PDC-E2 (amino acid 159–167), has been identified [89] and HLADR4*0101-restricted CD8 positive T cells from livers of patients with PBC have demonstrated cytotoxicity against PDC-E2 (amino acid 159–167) pulsed autologous cells [90]. The gene discussed is PDC; the disease is primary biliary cholangitis.