A prospective population-based study carried out in Germany has found that rates of severe hypoglycaemia (defined as a requirement for glucose or glucagon injection and blood glucose < 2.8 mmol/l) with glimepiride were significantly lower than with glibenclamide at 0.86 per 1000 person-years vs. 5.6 per 1000 person-years [38]. Here, GCG is linked to Hypoglycemia.