For example, the recent PROactive trial, comparing the addition of the peroxisome proliferator-activated receptor gamma (PPARγ)-agonist pioglitazone or placebo with usual diabetic treatment in Type 2 patients at high risk of vascular disease, found that the incidence of hypoglycaemia was significantly higher in the pioglitazone plus usual treatment group (28% vs. 20%, P < 0.001), although the incidence of severe hypoglycaemia (defined as hypoglycaemia which resulted in admission to hospital) was not significantly different (0.7% vs. 0.4%, P = 0.14). This evidence concerns the gene PPARG and Hypoglycemia.