Fifteen patients with PTEN-deficient tumors, who also met all other eligibility criteria (see Methods, Texts S2 and S3), were enrolled at the time of tumor recurrence and received neoadjuvant oral daily rapamycin (2 mg, 5 mg, or 10 mg per day) for approximately 1 wk (median: 6 d, mean: 7.5 d) (Table 1) prior to salvage surgical resection (S2). Here, PTEN is linked to neoplasm.