MKI67 and neoplasm: In contrast, there was no statistically significant relationship between time-to-progression and age (p = 0.57), Karnofsky performance status (p = 0.91), number of tumor recurrences prior to enrollment (p = 0.12), rapamycin levels in tumor (p = 0.45) or plasma (p = 0.25), inhibition of S6 phosphorylation at serine 240/44 (p = 0.42) or serine 235/236 (p = 0.65), basal phosphorylation of S6 at serine 240/244 (p = 0.24) or serine 235/236 (p = 0.54), or Ki-67 response (p = 0.42) (all p-values determined by Logrank test).