In essence, our findings along with Ladd et al. suggest a complex transcription within the FMR1 locus than previously thought and should provide an incentive for further studies to determine the exact nature of all the transcripts, and their function, throughout the FMR1 region and their relevance to FMR1-associated human disorders (fragile X syndrome and FXTAS). The gene discussed is FMR1; the disease is fragile X syndrome.