Interestingly, the PLA2G2A, PLA2G2C, PLA2G2D, PLA2G2E, PLA2G2F and PLA2G5 genes reside within the same region of human chromosome 1 at p35–36.1 (Valentin et al, 2000), a region frequently altered in colorectal cancer (Spirio et al, 1996). This evidence concerns the gene PLA2G2E and colorectal cancer.