To find out whether pulse selection with docetaxel had a general effect on CYP1B1 expression, a panel of docetaxel-selected cell lines – colon carcinoma Caco2, pancreatic carcinoma BxPc-3 and squamous cell lung carcinoma SK-MES-1 – and their parental counterparts were subjected to RT–PCR analysis. The gene discussed is CYP1B1; the disease is exocrine pancreatic carcinoma.