ADAM10 and melanoma: Other genes with consistent overexpression in tumor samples in comparison to nevi and skin (Fig. 5C) compatible with an oncogenic role include genes already associated to melanoma progression, such as FN1, which codes for the matrix protein fibronectin [88]; genes with proposed roles in tumor growth and metastasis, such as ADAM10, which encodes a putative desintegrin metallopeptidase [89], SGK, which encodes a glucocorticoid regulated kinase [90], NRP2, which encodes neuropilin 2[91], and also genes with no characterized function or association to cancer, such as C18orf19.