The high levels of MITF in WM1617 cells must explain the occurrence of many melanocytic markers (known MITF targets) in the Met library, as TYRP1, TYR, DCT, MLANA. However, differently from PLP1, high levels of MITF mRNA expression were not detected in the other three metastatic cell lines, but rather in cell lines from RGP and VGP tumor stages (WM35 and WM902). Here, MITF is linked to neoplasm.