PLP1 is a transmembrane protein involved in myelinization [75] whose up regulation was detected in leiomyomas [76] and melanoma cell lines [77], and although no previous study addresses the role of PLP1 in melanoma development, remarkably, we show here that all vertical growth phase and metastatic cell lines exhibit high expression levels of this gene. This evidence concerns the gene PLP1 and leiomyoma.