BRCA2 and breast carcinoma: Unlike breast cancer, where patients with germline mutations in BRCA1 or BRCA2 have cancers that are distinct from sporadic breast cancers on the basis of morphology or gene profiling [28-30], ovarian cancers with germline BRCA1 or BRCA2 mutations are indistinguishable from their sporadic counterparts [11,23,31-33].