BRCA2 and neoplasm: BRCA1, located at 17q21 [12-14], and BRCA2, located at 13q12-q13 [15,16] both encode tumor suppressors involved in repairing double-stranded DNA breaks and maintaining genomic stability [17-19] Germline BRCA1 or BRCA2 mutations are present in 10% to 15% of all EOCs [20,21].