ANXA5 and neoplasm: However, when incubated in the presence of both CHX and Poly I:C, the Annexin V/PI positive tumor cells significantly increased in the Hela cells and MCA38 cells (Hela and MCA38 up to about 40% and 70% respectively, Fig 3A, 3B), and few other tumor cell lines tested showed notable differences between apoptosis of tumor cells stimulated with CHX alone or poly I:C/CHX (data not shown).