CD4 and HIV-1 infection: As described above for liver and lung, HIV-1 infection resulted in a significant reduction of CD4+CCR5+ T cells in BLT mouse SI IEL (M1 − M2 = 21 ± 4.1, t = 5.1, df = 6, p = 0.002), SI LPL (M1 − M2 = 22 ± 8.5, t = 2.6, df = 6, p = 0.042), LI IEL (M1 − M2 = 38 ± 8.9, t = 4.3, df = 6, p = 0.005), and LI LPL (M1 − M2 = 48 ± 4.4, t = 11, df = 6, p < 0.001) (Figure 5C and 5D).