CCND1 and cancer: Aberrant cyclin D1 expression has been observed early in carcinogenesis (Barnes and Gillett 1998; Fusenig and Boukamp 1998; Weinstein 2000), and overexpression of cyclin D1 was reported in several human cancers, including uterine cervix (Nichols et al. 1996), ovary (Worsley et al. 1997), breast (Michalides et al. 1996), urinary bladder (Proctor et al. 1991), endometrium (Semczuk and Jakowicki 2004), and skin (Rodriguez-Puebla et al. 1999).