The enrichment of adhesive phenotypes is achieved by the panning procedure, where cytoadherent IRBCs are incubated either on isolated receptor molecules [15] or on receptor-expressing cells, such as amelanotic melanoma cells expressing CD36 [27], Saimiri brain endothelial cells (SBEC) expressing CSA and/or CD36 and ICAM-1 [28], human lung endothelial cells (HLEC) expressing CD36 and ICAM-1 [29], human choriocarcinoma cells expressing CSA and CD36 [30] or Chinese hamster ovary cells (CHO) transfected with the respective receptors [31]. This evidence concerns the gene ICAM1 and melanoma.